منابع مشابه
Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice.
Increased sarcoplasmic reticulum (SR) Ca2+ leak via the cardiac ryanodine receptor/calcium release channel (RyR2) is thought to play a role in heart failure (HF) progression. Inhibition of this leak is an emerging therapeutic strategy. To explore the role of chronic PKA phosphorylation of RyR2 in HF pathogenesis and treatment, we generated a knockin mouse with aspartic acid replacing serine 280...
متن کاملThe effect of β-adrenergic blockade on T wave alternans in patients with chronic heart failure
Sudden cardiac death is the most common and often first manifestation of atherosclerotic heart disease and is responsible for approximately 50% of the mortality from cardiovascular disease in the developed world. In the United States, 300,000 to 400,000 deaths annually are attributable to sudden cardiac death. This amounts to an overall incidence in the adult population of .1 .2 % per year. In ...
متن کاملb-Adrenergic Receptor Blockade in Chronic Heart Failure
The medical treatment of chronic heart failure has undergone a remarkable transition in the past 10 years. The approach has changed from a short-term hemodynamic/ pharmacological paradigm to a more long-term, reparative strategy that aims to favorably alter the biological properties of the failing heart.1 This is dramatically illustrated by the recent success in treating mild-to-moderate chroni...
متن کاملbeta-adrenergic receptor blockade in chronic heart failure.
-Adrenergic Receptor Blockade in Chronic Heart Failure β Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.101.5.558 2000;101:558-569 Circulation. http://circ.ahajournals.org/content/101/5/558 World Wide Web a...
متن کاملAldosterone blockade in heart failure.
Aldosterone plays a key role in the pathophysiology of heart failure. Angiotensin converting enzyme inhibitors and angiotensin II receptor blockers may not suppress aldosterone production in the long term. This allows aldosterone to exert its effects on myocardial fibrosis and cardiac remodelling, endothelial function, electrolytes and baroreceptor response. The Randomized Aldactone Evaluation ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2001
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.103.23.e118